Synthesis and evaluation of non-dimeric HCV NS5A inhibitors.
Bioorg Med Chem Lett
; 23(7): 2031-4, 2013 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-23466233
ABSTRACT
Based on the symmetrical bidentate structure of the NS5A inhibitor BMS-790052, a series of new monodentate molecules were designed. The synthesis of 36 new non-dimeric NS5A inhibitors is reported along with their ability to block HCV replication in an HCV 1b replicon system. Among them compound 5a showed picomolar range activity along with an excellent selectivity index (SI > 90,000).
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas não Estruturais Virais
/
Imidazóis
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos