Bupivacaine free plasma levels in children after caudal anaesthesia: influence of pretreatment with diazepam?
Fundam Clin Pharmacol
; 4(2): 159-61, 1990.
Article
em En
| MEDLINE
| ID: mdl-2351365
ABSTRACT
Diazepam-induced modifications in bupivacaine distribution have been noted in previously reported data investigating the influence of diazepam on bupivacaine plasma levels in children undergoing surgery under caudal block with a mixture of lignocaine and bupivacaine. Possible diazepam-induced changes in protein binding were therefore examined in this study. Our data did not demonstrate significant modifications in bupivacaine protein binding when diazepam is used concomitantly.
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Base de dados:
MEDLINE
Assunto principal:
Medicação Pré-Anestésica
/
Bupivacaína
/
Diazepam
/
Anestesia Caudal
/
Anestesia Epidural
Tipo de estudo:
Clinical_trials
Limite:
Child
/
Child, preschool
/
Humans
Idioma:
En
Revista:
Fundam Clin Pharmacol
Assunto da revista:
FARMACOLOGIA
Ano de publicação:
1990
Tipo de documento:
Article
País de afiliação:
França