Cellular events associated with peripherally induced rejection of mature neural xenografts placed into neonatal rat brains.
J Comp Neurol
; 295(3): 428-37, 1990 May 15.
Article
em En
| MEDLINE
| ID: mdl-2351761
ABSTRACT
Various circumstances have brought about a dispute concerning the immunologically priviledged status of the central nervous system (CNS). Using a transplantation paradigm, we have examined the cellular events associated with an experimentally induced focal assault on the CNS by the immune system. Chunks of embryonic mouse cortex were transplanted into neonatal rat brains and allowed to survive for 4 weeks. The adult rats then received a skin graft of donor origin to induce rejection of the transplanted tissue. Animals were sacrificed at various time points and examined histologically and immunocytochemically. Under these circumstances, the transplant is rejected via a first-set rejection response, and astrocytes of donor origin appear to be the primary target of the host immune system. Expression of class I and class II major histocompatibility antigens is noted to correlate with lymphocytic invasion of the transplant.
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Base de dados:
MEDLINE
Assunto principal:
Transplante Heterólogo
/
Córtex Cerebral
/
Astrócitos
/
Rejeição de Enxerto
/
Complexo Principal de Histocompatibilidade
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
J Comp Neurol
Ano de publicação:
1990
Tipo de documento:
Article