Signalling by the ßc family of cytokines.
Cytokine Growth Factor Rev
; 24(3): 189-201, 2013 Jun.
Article
em En
| MEDLINE
| ID: mdl-23535386
ABSTRACT
The GM-CSF, IL-3 and IL-5 family of cytokines, also known as the ßc family due to their receptors sharing the signalling subunit ßc, regulates multiple biological processes such as native and adaptive immunity, inflammation, normal and malignant hemopoieis, and autoimmunity. Australian scientists played a major role in the discovery and biological characterisation of the ßc cytokines and their recent work is revealing unique features of cytokine receptor assembly and signalling. Furthermore, specific antibodies have been generated to modulate their function. Characterisation of the structural and dynamic requirements for the activation of the ßc receptor family and the molecular definition of downstream signalling pathways are providing new insights into cytokine receptor signalling as well as new therapeutic opportunities.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
Citocinas
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cytokine Growth Factor Rev
Assunto da revista:
ALERGIA E IMUNOLOGIA
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BIOQUIMICA
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Austrália