Hypoallergenicity and immunological characterization of enzyme-treated royal jelly from Apis mellifera.
Biosci Biotechnol Biochem
; 77(4): 789-95, 2013.
Article
em En
| MEDLINE
| ID: mdl-23563566
ABSTRACT
Royal jelly (RJ), the exclusive food for queen bees, is taken as a dietary supplement because it is highly rich in nutrients. However, RJ is known to induce an anaphylactic response in some individuals. We evaluated in the present study the hypoallergenicity of alkaline protease-treated RJ in vitro and in vivo. We first confirmed that this treated RJ contained the same levels of vitamins, minerals and specific fatty acid as in untreated RJ. We then showed that the IgE-binding capacity of the treated RJ was very significantly reduced by conducting in vitro assays of the blood from RJ-sensitive patients. An in vivo skin-prick test on the RJ-sensitive patients also showed that, in the majority of the patients (3 out of 4 tested), the treated RJ did not evoke any allergenic response. It is thus advantageous to prepare hypoallergenic RJ by a protease enzyme treatment for its safe consumption.
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Base de dados:
MEDLINE
Assunto principal:
Endopeptidases
/
Proteínas de Bactérias
/
Abelhas
/
Alérgenos
/
Ácidos Graxos
Limite:
Adult
/
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Biosci Biotechnol Biochem
Assunto da revista:
BIOQUIMICA
/
BIOTECNOLOGIA
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Japão