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Identification of a small molecule that induces ATG5-and-cathepsin-l-dependent cell death and modulates polyglutamine toxicity.
Varma, Hemant; Gangadhar, Nidhi M; Letso, Reka R; Wolpaw, Adam J; Sriramaratnam, Rohitha; Stockwell, Brent R.
Afiliação
  • Varma H; Howard Hughes Medical Institute, Department of Biological Sciences, Columbia University, Northwest Corner Building, MC 4846, 550 West 120th Street, New York, NY 10027, United States; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, United States.
  • Gangadhar NM; Howard Hughes Medical Institute, Department of Biological Sciences, Columbia University, Northwest Corner Building, MC 4846, 550 West 120th Street, New York, NY 10027, United States.
  • Letso RR; Howard Hughes Medical Institute, Department of Biological Sciences, Columbia University, Northwest Corner Building, MC 4846, 550 West 120th Street, New York, NY 10027, United States.
  • Wolpaw AJ; Howard Hughes Medical Institute, Department of Biological Sciences, Columbia University, Northwest Corner Building, MC 4846, 550 West 120th Street, New York, NY 10027, United States.
  • Sriramaratnam R; Howard Hughes Medical Institute, Department of Biological Sciences, Columbia University, Northwest Corner Building, MC 4846, 550 West 120th Street, New York, NY 10027, United States.
  • Stockwell BR; Howard Hughes Medical Institute, Department of Biological Sciences, Columbia University, Northwest Corner Building, MC 4846, 550 West 120th Street, New York, NY 10027, United States; Department of Chemistry, Columbia University, Northwest Corner Building, MC 4846, 550 West 120th Street, New York, NY
Exp Cell Res ; 319(12): 1759-1773, 2013 Jul 15.
Article em En | MEDLINE | ID: mdl-23588206
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autofagia / Tiofenos / Catepsina L / Proteínas Associadas aos Microtúbulos Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Exp Cell Res Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autofagia / Tiofenos / Catepsina L / Proteínas Associadas aos Microtúbulos Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Exp Cell Res Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Estados Unidos