VCAM-1 serum levels are associated with arthropathy in hereditary haemochromatosis.
Ann Rheum Dis
; 72(12): 2006-10, 2013 Dec.
Article
em En
| MEDLINE
| ID: mdl-23599437
ABSTRACT
OBJECTIVES:
The aim of this study was to assess the role of vascular adhesion molecule 1 (VCAM-1) in patients with hereditary haemochromatosis (HH) with or without arthropathy.METHODS:
Sera from a large cross-sectional cohort of unselected HH patients (n=147) were obtained and compared to an age-matched and sex-matched control group. Serum levels of VCAM-1 were measured by ELISA and were correlated with clinical measures.RESULTS:
VCAM-1 serum levels were elevated in HH patients as compared to matched controls (mean 913±456 vs 654±451 ng/ml, p<0.0001). Within the HH patient group, VCAM-1 levels were much higher in patients with arthropathy and joint replacement surgery. VCAM-1 levels correlated well with radiographic measures of HH arthropathy (r=0.36, p<0.0001). Multivariate regression analysis confirmed a highly significant association of VCAM-1 serum levels and the presence of HH arthropathy, independent from diabetes, body mass index and age.CONCLUSIONS:
VCAM-1 serum levels emerge as a biomarker for haemochromatosis arthropathy.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Artrite
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Molécula 1 de Adesão de Célula Vascular
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Hemocromatose
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Observational_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Ann Rheum Dis
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Áustria