Structure, function, and biology of the Enterococcus faecalis cytolysin.
Toxins (Basel)
; 5(5): 895-911, 2013 Apr 29.
Article
em En
| MEDLINE
| ID: mdl-23628786
ABSTRACT
Enterococcus faecalis is a Gram-positive commensal member of the gut microbiota of a wide range of organisms. With the advent of antibiotic therapy, it has emerged as a multidrug resistant, hospital-acquired pathogen. Highly virulent strains of E. faecalis express a pore-forming exotoxin, called cytolysin, which lyses both bacterial and eukaryotic cells in response to quorum signals. Originally described in the 1930s, the cytolysin is a member of a large class of lanthionine-containing bacteriocins produced by Gram-positive bacteria. While the cytolysin shares some core features with other lantibiotics, it possesses unique characteristics as well. The current understanding of cytolysin biosynthesis, structure/function relationships, and contribution to the biology of E. faecalis are reviewed, and opportunities for using emerging technologies to advance this understanding are discussed.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Bacteriocinas
/
Enterococcus faecalis
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Toxins (Basel)
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos