Histamine enhances HIV-1-induced modulation of dendritic cells to skew naïve T cell differentiation toward regulatory T cells.
Virology
; 442(2): 163-72, 2013 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-23652320
ABSTRACT
Altered cytokine profiles and imbalanced frequencies of CD4(+) T helper cell subsets are thought to be linked with HIV-1/AIDS pathogenesis, but the causes need to be further clarified. Histamine, a biogenic amine with many functions, shows enhancement in HIV-1 infected individuals, which are considered to link with disease progression, but is poorly understood. This study investigated histamine-assisted HIV-1 modulation of dendritic cell (DC) functions. Histamine and HIV-1 showed a synergistic role in induction of interleukin-10; histamine inhibited HIV-1-induced IL-12 production from MDDCs (monocyte-derived DCs); notably, histamine augmented HIV-1-induced MDDC functional polarization and skewed naïve T cell differentiation toward regulatory T cells (Tregs). The results indicate the novel role of histamine in HIV-1-induced DC functional regulation, which promoted Treg cell differentiation and up-regulated immunosuppressive factors. These findings help to bridge the correlation between elevated histamine and increased Treg cell frequency in HIV-1 infected individuals, and add to our understanding of HIV-1-induced immunosuppression.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Células Dendríticas
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Histamina
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HIV-1
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Linfócitos T Reguladores
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Fatores Imunológicos
Limite:
Humans
Idioma:
En
Revista:
Virology
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
China