Evaluation of the retinoids with cisplatin and vincristine in xenograft models of neuroblastoma.
J Pediatr Hematol Oncol
; 36(1): e23-7, 2014 Jan.
Article
em En
| MEDLINE
| ID: mdl-23669732
ABSTRACT
Retinoids have been studied for the treatment of children with neuroblastoma for >25 years. Posttransplant administration of isotretinoin is standard of care for children with high-risk neuroblastoma, whereas fenretinide remains investigational. Previous preclinical studies have evaluated the interaction of retinoids and cytotoxic agents with conflicting results. We evaluated the schedule-dependent interaction of the cytotoxic agents, vincristine and cisplatin, with the retinoids, isotretinoin and fenretinide, in xenograft models of neuroblastoma. Concomitant administration of isotretinoin or fenretinide with the cytotoxic agents did not result in any clear potentiation of cytotoxicity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Retinoides
/
Vincristina
/
Cisplatino
/
Neoplasias do Sistema Nervoso
/
Neuroblastoma
Limite:
Animals
Idioma:
En
Revista:
J Pediatr Hematol Oncol
Assunto da revista:
HEMATOLOGIA
/
NEOPLASIAS
/
PEDIATRIA
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Panamá