No evidence of cardiomyopathy in spinal and bulbar muscular atrophy.
Acta Neurol Scand
; 128(6): e30-2, 2013 Dec.
Article
em En
| MEDLINE
| ID: mdl-23679084
ABSTRACT
OBJECTIVES:
Spinal and bulbar muscular atrophy (SBMA) is a lower motor neuron disease caused by a CAG repeat expansion within the androgen receptor (AR) gene. Toxic nuclear accumulation of mutant AR has been observed in tissues other than nervous system including cardiac muscle. Moreover, CAG polymorphism length within AR has been associated with an increased risk of heart disease. MATERIALS ANDMETHODS:
To test the hypothesis of the presence of cardiomyopathy in SBMA, a full cardiac protocol was applied to 25 SBMA patients.RESULTS:
Patients' age ranged between 32 and 75 years. Cardiologic examination, 12-lead ECG, and echocardiography showed no abnormalities other than those consistent with hypertensive heart disease. One patient showed frequent supraventricular premature beats in absence of other significant arrhythmias at the 24-h ECG Holter.CONCLUSIONS:
Our findings do not support the hypothesis of a primary cardiomyopathy in SBMA.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transtornos Musculares Atróficos
/
Cardiomiopatias
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Acta Neurol Scand
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Itália