Non-AIDS-related Kaposi's sarcoma: A single-institution experience.
World J Clin Oncol
; 4(2): 52-7, 2013 May 10.
Article
em En
| MEDLINE
| ID: mdl-23696963
ABSTRACT
AIM:
To evaluate the outcomes and potential prognostic factors in patients with non-acquired immunodeficiency syndrome (AIDS)-related Kaposi's sarcoma (KS).METHODS:
Patients with histologically proven non-AIDS-related KS treated with systemic chemotherapy were included in this retrospective analysis. In some cases, the human herpes virus 8 status was assessed by immunohistochemistry. The patients were staged according to the Mediterranean KS staging system. A multivariable model was constructed using a forward stepwise selection procedure. A P value < 0.05 was considered statistically significant, and all tests were two-sided.RESULTS:
Thirty-two cases were included in this analysis. The average age at diagnosis was 70 years, with a male/female ratio of approximately 21. Eighty-four percent of the cases had classic KS. All patients received systemic chemotherapy containing one of the following agents vinca alkaloid, taxane, and pegylated liposomal doxorubicin. Ten patients (31.5%) experienced a partial response, and a complete response was achieved in four patients (12.4%) and stable disease in sixteen cases (50%). Two patients (6.2%) were refractory to the systemic treatment. The median progression-free survival (PFS) was 11.7 mo, whereas the median overall survival was 28.5 mo. At multivariate analysis, the presence of nodular lesions (vs macular lesions only) was significantly related to a lower PFS (hazard ratio 3.09; 95%CI 1.18-8.13, P = 0.0133).CONCLUSION:
Non-AIDS-related KS appears mostly limited to the skin and is well-responsive to systemic therapies. Our data show that nodular lesions may be associated with a shorter PFS in patients receiving chemotherapy.
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Base de dados:
MEDLINE
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
World J Clin Oncol
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Itália