Epigenetic regulation on gene expression induced by physical exercise.
J Musculoskelet Neuronal Interact
; 13(2): 133-46, 2013 Jun.
Article
em En
| MEDLINE
| ID: mdl-23728100
ABSTRACT
It is well established that physical exercise modulates the function of many physiological systems, such as the musculoskeletal, the cardiovascular and the nervous system, by inducing various adaptations to the increased mechanical load and/or metabolic stress of exercise. Many of these changes occur through epigenetic alterations to DNA, such as histone modifications, DNA methylations, expression of microRNAs and changes of the chromatin structure. All these epigenetic alterations may have clinical relevance, thus playing an important role in the prevention and confrontation of neurophysiological disorders, metabolic syndrome, cardiovascular diseases and cancer. Herein we review the known epigenetic modifications induced by physical exercise in various physiological systems and pathologies, and discuss their potential clinical implications.
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Base de dados:
MEDLINE
Assunto principal:
Exercício Físico
/
Expressão Gênica
/
Epigênese Genética
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Musculoskelet Neuronal Interact
Assunto da revista:
FISIOLOGIA
/
NEUROLOGIA
/
ORTOPEDIA
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Grécia