An undesired effect of chemotherapy: gemcitabine promotes pancreatic cancer cell invasiveness through reactive oxygen species-dependent, nuclear factor &#954;B- and hypoxia-inducible factor 1&#945;-mediated up-regulation of CXCR4.

Arora, Sumit; Bhardwaj, Arun; Singh, Seema; Srivastava, Sanjeev K; McClellan, Steven; Nirodi, Chaitanya S; Piazza, Gary A; Grizzle, William E; Owen, Laurie B; Singh, Ajay P

An undesired effect of chemotherapy: gemcitabine promotes pancreatic cancer cell invasiveness through reactive oxygen species-dependent, nuclear factor κB- and hypoxia-inducible factor 1α-mediated up-regulation of CXCR4.

Arora, Sumit; Bhardwaj, Arun; Singh, Seema; Srivastava, Sanjeev K; McClellan, Steven; Nirodi, Chaitanya S; Piazza, Gary A; Grizzle, William E; Owen, Laurie B; Singh, Ajay P.

Afiliação

Arora S; From the Department of Oncologic Sciences, Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama 36604.
Bhardwaj A; From the Department of Oncologic Sciences, Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama 36604.
Singh S; From the Department of Oncologic Sciences, Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama 36604.
Srivastava SK; From the Department of Oncologic Sciences, Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama 36604.
McClellan S; From the Department of Oncologic Sciences, Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama 36604.
Nirodi CS; From the Department of Oncologic Sciences, Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama 36604.
Piazza GA; From the Department of Oncologic Sciences, Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama 36604.
Grizzle WE; the Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, and.
Owen LB; From the Department of Oncologic Sciences, Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama 36604.
Singh AP; From the Department of Oncologic Sciences, Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama 36604,; the Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama, Mobile, Alabama 36688. Electronic address: asingh@usouthal.edu.

J Biol Chem ; 288(29): 21197-21207, 2013 Jul 19.

Article em En | MEDLINE | ID: mdl-23740244

Assuntos

Desoxicitidina/análogos & derivados; Subunidade alfa do Fator 1 Induzível por Hipóxia/metabolismo; NF-kappa B/metabolismo; Neoplasias Pancreáticas/patologia; Espécies Reativas de Oxigênio/metabolismo; Receptores CXCR4/genética; Regulação para Cima/efeitos dos fármacos; Linhagem Celular Tumoral; Movimento Celular/efeitos dos fármacos; Movimento Celular/genética; Desoxicitidina/efeitos adversos; Desoxicitidina/farmacologia; Ativação Enzimática/efeitos dos fármacos; MAP Quinases Reguladas por Sinal Extracelular/metabolismo; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Humanos; Invasividade Neoplásica; Neoplasias Pancreáticas/enzimologia; Neoplasias Pancreáticas/genética; Proteínas Proto-Oncogênicas c-akt/metabolismo; Receptores CXCR4/metabolismo; Fator de Transcrição RelA/metabolismo; Transcrição Gênica/efeitos dos fármacos; Regulação para Cima/genética; Gencitabina

Palavras-chave

CXCR4; Chromatography; Hypoxia-inducible Factor (HIF); NF-κB; Pancreatic Cancer; Reactive Oxygen Species (ROS)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Regulação para Cima / NF-kappa B / Espécies Reativas de Oxigênio / Receptores CXCR4 / Desoxicitidina / Subunidade alfa do Fator 1 Induzível por Hipóxia Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2013 Tipo de documento: Article

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