N staging of lung cancer patients with PET/MRI using a three-segment model attenuation correction algorithm: initial experience.
Eur Radiol
; 23(11): 3161-9, 2013 Nov.
Article
em En
| MEDLINE
| ID: mdl-23765261
ABSTRACT
OBJECTIVES:
Evaluate the performance of PET/MRI at tissue interfaces with different attenuation values for detecting lymph node (LN) metastases and for accurately measuring maximum standardised uptake values (SUVmax) in lung cancer patients. MATERIALS ANDMETHOD:
Eleven patients underwent PET/CT and PET/MRI for staging, restaging or follow-up of suspected or known lung cancer. Four experienced readers determined the N stage of the patients for each imaging method in a randomised blinded way. Concerning metastases, SUVmax of FDG-avid LNs were measured in PET/CT and PET/MRI in all patients. A standard of reference was created with a fifth experienced independent reader in combination with a chart review. Results were analysed to determine interobserver agreement, SUVmax correlation between CT and MRI (three-segment model) attenuation correction and diagnostic performance of the two techniques.RESULTS:
Overall interobserver agreement was high (κ = 0.86) for PET/CT and substantial (κ = 0.70) for PET/MRI. SUVmax showed strong positive correlation (Spearman's correlation coefficient = 0.93, P < 0.001) between the two techniques. Diagnostic performance of PET/MRI was slightly inferior to that of PET/CT, without statistical significance (P > 0.05).CONCLUSIONS:
PET/MRI using three-segment model attenuation correction for LN staging in lung cancer shows a strong parallel to PET/CT in terms of SUVmax, interobserver agreement and diagnostic performance. KEY POINTS â¢F18-FDG PET/MRI shows similar performance to F18-FDG PET/CT in lung cancer N staging. â¢PET/MRI has substantial interobserver agreement in N staging. â¢A three-segment model attenuation correction is reliable for assessing the mediastinum.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Algoritmos
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Imageamento por Ressonância Magnética
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Tomografia Computadorizada por Raios X
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Imageamento Tridimensional
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Tomografia por Emissão de Pósitrons
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Neoplasias Pulmonares
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Estadiamento de Neoplasias
Tipo de estudo:
Clinical_trials
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Diagnostic_studies
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Observational_studies
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Prognostic_studies
Limite:
Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
Eur Radiol
Assunto da revista:
RADIOLOGIA
Ano de publicação:
2013
Tipo de documento:
Article