PPAR activation as a regulator of lipid metabolism, nitric oxide production and lipid peroxidation in the placenta from type 2 diabetic patients.
Mol Cell Endocrinol
; 377(1-2): 7-15, 2013 Sep 05.
Article
em En
| MEDLINE
| ID: mdl-23811234
ABSTRACT
Peroxisome proliferator activated receptors (PPARs) are ligand activated transcription factors with crucial functions in lipid homeostasis, anti-inflammatory processes and placental development. Maternal diabetes induces a pro-inflammatory environment and alters placental development. We investigated whether PPARs regulate lipid metabolism and nitric oxide (NO) production in placental explants from healthy and type 2 diabetic (DM2) patients. We found decreased PPARα and PPARγ concentrations, no changes in PPARδ concentrations, and increased lipids, lipoperoxides and NO production in placentas from DM2 patients. PPARα agonists reduced placental concentrations of triglycerides and both PPARα and PPARδ agonists reduced concentrations of phospholipids, cholesteryl esters and cholesterol. PPARγ agonists increased lipid concentrations in placentas from DM2 patients and more markedly in placentas from healthy patients. Endogenous ligands for the three PPAR isotypes reduced NO production and lipoperoxidation in placentas from DM2 patients. We conclude that PPARs play a role in placental NO and lipid homeostasis and can regulate NO production, lipid concentrations and lipoperoxidation in placentas from DM2 patients.
Palavras-chave
15dPGJ(2); 15deoxyΔ(12,14)PGJ(2); Clof; Diabetes in pregnancy; GDM; GW; GW501516; LTB(4); Lipid metabolism; NO; Nitric oxide; PG; PGI(2); PPAR; PPARs; Placenta; Rosi; TBARS; cPGI(2); carbaprostacyclin; clofibrate; gestational diabetes mellitus; leukotriene B(4); nitric oxide; peroxisome proliferator activated receptor; prostacyclin or prostaglandin I(2); prostaglandin; rosiglitazone; thiobarbituric acid reactive substances
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Placenta
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Peroxidação de Lipídeos
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Receptores Ativados por Proliferador de Peroxissomo
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Diabetes Mellitus Tipo 2
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Metabolismo dos Lipídeos
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Óxido Nítrico
Limite:
Adult
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Female
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Humans
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Pregnancy
Idioma:
En
Revista:
Mol Cell Endocrinol
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Argentina