Children often present with infantile spasms after herpetic encephalitis.
Epilepsia
; 54(9): 1571-6, 2013 Sep.
Article
em En
| MEDLINE
| ID: mdl-23815601
ABSTRACT
PURPOSE:
To determine what epilepsy types occur after herpetic encephalitis and what are the determinant factors for subsequent infantile spasms.METHODS:
We analyzed retrospectively the clinical history of 22 patients, referred to Necker and Saint Vincent de Paul Hospitals (Paris) through the French pediatric epilepsy network from March 1986 to April 2010 and who developed epilepsy some months after herpetic encephalitis. We focused on seizure semiology with video-electroencephalography (EEG) recording, and on neuroradiology and epilepsy follow-up. KEYFINDINGS:
Fourteen patients developed pharmacoresistant spasms, and eight developed focal epilepsy, but none had both. The patients who developed spasms were more frequently younger than 30 months at age of onset of epilepsy and had herpetic encephalitis earlier (mean 10.6 months of age) than those who developed focal epilepsy (mean 59.7 and 39.6 months, respectively). Epilepsy follow-up was similar in both groups (8.5 and 11 years, respectively). We found 26 affected cerebral areas; none alone was related to the development of epileptic spasms.SIGNIFICANCE:
Risk factors to develop epileptic spasms were to have had herpetic encephalitis early (mean 10 months); to be significantly younger at onset of epilepsy (mean 22.1 months); and to have cerebral lesions involving the insula, the hippocampus, and the temporal pole.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Espasmos Infantis
/
Encefalite por Herpes Simples
Tipo de estudo:
Etiology_studies
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Observational_studies
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Risk_factors_studies
Limite:
Child
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Child, preschool
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Humans
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Infant
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Newborn
Idioma:
En
Revista:
Epilepsia
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Espanha