Relationship between trough plasma and epithelial lining fluid concentrations of voriconazole in lung transplant recipients.
Antimicrob Agents Chemother
; 57(9): 4581-3, 2013 Sep.
Article
em En
| MEDLINE
| ID: mdl-23817382
ABSTRACT
Trough (predose) voriconazole concentrations in plasma and pulmonary epithelial lining fluid (ELF) of lung transplant recipients receiving oral voriconazole preemptive treatment were determined. The mean (± standard deviation [SD]) ELF/plasma ratio was 12.5 ± 6.3. A strong positive linear relationship was noted between trough plasma and ELF voriconazole concentrations (r(2) = 0.87), suggesting the feasibility of using trough plasma voriconazole concentration as a surrogate to estimate the corresponding concentration in ELF of lung transplant recipients.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pirimidinas
/
Triazóis
/
Líquido da Lavagem Broncoalveolar
/
Transplante de Pulmão
/
Micoses
/
Antifúngicos
Tipo de estudo:
Observational_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Antimicrob Agents Chemother
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Austrália