Enantioselective construction of dihydropyran-fused indoles through chiral calcium phosphate catalyzed oxo-hetero-Diels-Alder reactions by using 2-oxoindolin-3-ylidenes as heterodienes.
Chemistry
; 19(30): 9754-9, 2013 Jul 22.
Article
em En
| MEDLINE
| ID: mdl-23832817
ABSTRACT
Carbon-carbon bond formation A highly efficient method for the oxo-hetero-Diels-Alder reaction of 2-oxoindolin-3-ylidenes based on chiral calcium phosphate is described. In general, adducts were obtained with high yields and excellent diastereo- and enantioselectivities (up to 96 % yield, >991 endo/exo, >99 %â
ee; see scheme, Boc = tert-butoxycarbonyl).
Texto completo:
1
Base de dados:
MEDLINE
Idioma:
En
Revista:
Chemistry
Assunto da revista:
QUIMICA
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
China