[Pneumocystis: epidemiology and molecular approaches]. / Pneumocystis : épidémiologie et approches moléculaires.
Pathol Biol (Paris)
; 61(6): 239-44, 2013 Dec.
Article
em Fr
| MEDLINE
| ID: mdl-23849772
ABSTRACT
Pneumocystosis is a common opportunistic infection in immunocompromised patients, especially in AIDS patients. The diagnosis of this pneumonia has presented several difficulties due to the low sensitivity of conventional staining methods and the absence of culture system for Pneumocystis. The molecular biology techniques, especially the PCR, have improved the detection of DNA of this fungus in invasive and noninvasive samples, and in the environment which highlighted human transmission and the existence of environmental source of Pneumocystis. In addition, various molecular biology techniques were used for typing of Pneumocystis strains, especially P. jirovecii, which is characterized by a significant genetic biodiversity. Finally, the widespread use of cotrimoxazole for the treatment and prophylaxis of pneumocystosis has raised questions about possible resistance to sulfa drugs in P. jirovecii.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pneumocystis
/
Pneumonia por Pneumocystis
Tipo de estudo:
Screening_studies
Limite:
Animals
/
Humans
Idioma:
Fr
Revista:
Pathol Biol (Paris)
Ano de publicação:
2013
Tipo de documento:
Article