The triterpenoid fraction from Trichosanthes dioica root suppresses experimentally induced inflammatory ascites in rats.
Pharm Biol
; 51(11): 1477-9, 2013 Nov.
Article
em En
| MEDLINE
| ID: mdl-23855777
ABSTRACT
CONTEXT Trichosanthes dioica Roxb. (Cucurbitaceae), called pointed gourd in English, is a dioecious climber found wild throughout the plains of the Indian subcontinent and traditionally used in India for several medicinal purposes. OBJECTIVE:
The present study evaluated the protective effect of the triterpenoid enriched fraction from T. dioica root (CETD) against experimentally induced acute inflammatory ascites in Wistar albino rats. MATERIALS ANDMETHODS:
The CETD was administered orally at the different doses (25, 50 and 100 mg/kg body weight) to overnight fasted rats, and then ascites was induced by intraperitoneal administration of formalin solution. After 7 h, the rats were sacrificed and the volume of ascitic fluid was measured.RESULTS:
The CETD demonstrated significant (p < 0.01) reduction of ascitic fluid formation in a dose-dependent manner as compared with control.CONCLUSION:
The CETD produced significant and dose-dependent inhibition of experimentally induced inflammatory ascites in Wistar albino rats.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ascite
/
Triterpenos
/
Extratos Vegetais
/
Trichosanthes
/
Inflamação
/
Anti-Infecciosos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Pharm Biol
Ano de publicação:
2013
Tipo de documento:
Article