Enzyme-catalyzed conversion of chemical structures on the surface of gold nanorods.
Bioconjug Chem
; 24(9): 1435-44, 2013 Sep 18.
Article
em En
| MEDLINE
| ID: mdl-23889000
ABSTRACT
For developing metal nanoparticles of which surface chemical structures could be altered by enzymes in the cells, functional linkers caged by coumaric acids have been synthesized. Synthesized gold nanorod (GNR) conjugates possessing coumaric acid precursors underwent (porcine liver) esterase-catalyzed hydrolysis on their surface to afford GNRs coated with amino-functionalized polyethylene glycol and fluorescent coumarins as reporter molecules for monitoring the conversion. The chemical structural conversion on the GNR surfaces was successfully observed inside cells by fluorescence microscopy when GNR conjugates were incubated with tumor cells.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Nanotubos
/
Nanopartículas Metálicas
/
Ouro
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Bioconjug Chem
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Japão