Electrical stimulation and testosterone enhance recovery from recurrent laryngeal nerve crush.
Restor Neurol Neurosci
; 33(4): 571-8, 2015.
Article
em En
| MEDLINE
| ID: mdl-23902984
ABSTRACT
OBJECTIVE:
This study investigated the effects of a combinatorial treatment, consisting of a brief period of nerve electrical stimulation (ES) and systemic supraphysiologic testosterone, on functional recovery following a crush of the recurrent laryngeal nerve (RLN). STUDYDESIGN:
Prospective, controlled animal study.METHODS:
After a crush of the left RLN, adult male Sprague-Dawley rats were divided into four treatment groups 1) no treatment, 2) ES, 3) testosterone propionate (TP), and 4) ES + TP. Each group was subdivided into 1, 2, 3, or 4 weeks post-operative survival time points. Groups had an n of 4- 9. Recovery of vocal fold mobility (VFM) was assessed.RESULTS:
Brief ES of the proximal nerve alone or in combination with TP accelerated the initiation of functional recovery. TP administration by itself also produced increased VFM scores compared to controls, but there were no statistical differences between the ES-treated and TP-treated animals. Treatment with brief ES alone was sufficient to decrease the time required to recover complete VFM. Animals with complete VFM were seen in treatment groups as early as 1 week following injury; in the untreated group, this was not observed until at least 3 weeks post-injury, translating into a 66% decrease in time to complete recovery.CONCLUSIONS:
Brief ES, alone or in combination with TP, promise to be effective therapeutic interventions for promoting regeneration following RLN injury.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Terapia por Estimulação Elétrica
/
Fármacos Neuroprotetores
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Propionato de Testosterona
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Traumatismos do Nervo Laríngeo Recorrente
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Hormônios
Tipo de estudo:
Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
Restor Neurol Neurosci
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Estados Unidos