Suppression of late phase enhanced vascular permeability in rats by selective depletion of neutrophils with a monoclonal antibody.
J Leukoc Biol
; 48(3): 258-65, 1990 Sep.
Article
em En
| MEDLINE
| ID: mdl-2391449
ABSTRACT
We investigated the role of neutrophils in increased vascular permeability by a selective reduction of neutrophils using a monoclonal antibody, RP-3. An intraperitoneal injection of RP-3 not only selectively depleted peripheral blood neutrophils, but prevented the neutrophil infiltration to the tissues. Proteose peptone, zymosan, and BCG induced three different types of inflammatory edema, showing the early phase only, early plus late phase, and the late phase only, respectively. Only the late phase response of zymosan and BCG was inhibited by a depletion of neutrophils by RP-3, though the early phase response induced by proteose peptone and zymosan was not affected. Reconstitution of neutrophil-depleted rats by in situ injection of these cells restored the inflammatory edema induced by BCG, depending upon the number of neutrophils injected.
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Base de dados:
MEDLINE
Assunto principal:
Permeabilidade Capilar
/
Anticorpos Monoclonais
/
Neutrófilos
Limite:
Animals
Idioma:
En
Revista:
J Leukoc Biol
Ano de publicação:
1990
Tipo de documento:
Article
País de afiliação:
Japão