Cytochrome c and superoxide: a reply.

ABSTRACT

In his comments, W.H. Koppenol criticizes our article with respect to our conclusions and procedures. In this answer, we respond in detail to his objections, demonstrating that the approaches used are commonly accepted in the literature and that he makes a number of assumptions regarding our proposed mechanism that are not justified. Our study is thus a contribution to the ongoing investigation of the behavior of cytochrome c.