Immune tolerance negatively regulates B cells in knock-in mice expressing broadly neutralizing HIV antibody 4E10.

Doyle-Cooper, Colleen; Hudson, Krystalyn E; Cooper, Anthony B; Ota, Takayuki; Skog, Patrick; Dawson, Phillip E; Zwick, Michael B; Schief, William R; Burton, Dennis R; Nemazee, David

Doyle-Cooper, Colleen; Hudson, Krystalyn E; Cooper, Anthony B; Ota, Takayuki; Skog, Patrick; Dawson, Phillip E; Zwick, Michael B; Schief, William R; Burton, Dennis R; Nemazee, David.

Afiliação

Doyle-Cooper C; Department of Immunology and Microbial Science, The Scripps Research Institute.
Hudson KE; Department of Immunology and Microbial Science, The Scripps Research Institute.
Cooper AB; Department of Immunology and Microbial Science, The Scripps Research Institute.
Ota T; Department of Immunology and Microbial Science, The Scripps Research Institute.
Skog P; Department of Immunology and Microbial Science, The Scripps Research Institute.
Dawson PE; Department of Chemistry, The Scripps Research Institute.
Zwick MB; Department of Immunology and Microbial Science, The Scripps Research Institute.
Schief WR; Department of Immunology and Microbial Science, The Scripps Research Institute.
Burton DR; IAVI Neutralizing Antibody Center.
Nemazee D; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute.

J Immunol ; 191(6): 3186-3191, 2013 Sep 15.

Article em En | MEDLINE | ID: mdl-23940276

Assuntos

Anticorpos Neutralizantes/imunologia; Linfócitos B/imunologia; Anticorpos Anti-HIV/imunologia; Proteína gp41 do Envelope de HIV/imunologia; Tolerância Imunológica/imunologia; Vacinas contra a AIDS/imunologia; Animais; Anticorpos Neutralizantes/sangue; Ensaio de Imunoadsorção Enzimática; Citometria de Fluxo; Técnicas de Introdução de Genes; Anticorpos Anti-HIV/sangue; Antígenos HIV/imunologia; Proteína gp120 do Envelope de HIV/imunologia; Cadeias Pesadas de Imunoglobulinas/genética; Cadeias Pesadas de Imunoglobulinas/imunologia; Cadeias Leves de Imunoglobulina/genética; Cadeias Leves de Imunoglobulina/imunologia; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Transgênicos

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos B / Anticorpos Anti-HIV / Proteína gp41 do Envelope de HIV / Anticorpos Neutralizantes / Tolerância Imunológica Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Immunol Ano de publicação: 2013 Tipo de documento: Article

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