Schistosomiasis japonica during pregnancy is associated with elevated endotoxin levels in maternal and placental compartments.
J Infect Dis
; 209(3): 468-72, 2014 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-23964108
ABSTRACT
Schistosomiasis affects approximately 40 million women of reproductive age and has been linked to elevated levels of circulating endotoxin in nonpregnant individuals. We have evaluated endotoxin levels in maternal, placental, and newborn blood collected from women residing in Leyte, Philippines. Endotoxin levels in both maternal and placental compartments in pregnant women with schistosomiasis were 1.3- and 2.4-fold higher, respectively, than in uninfected women. In addition, higher concentrations of endotoxin in placental blood were associated with premature birth, acute chorioamnionitis, and elevated proinflammatory cytokines. By promoting endotoxemia, schistosomiasis may exert additional, maladaptive influences on pregnancy outcomes.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Análise Química do Sangue
/
Esquistossomose Japônica
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Complicações Parasitárias na Gravidez
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Endotoxinas
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Sangue Fetal
Tipo de estudo:
Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Newborn
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Pregnancy
País/Região como assunto:
Asia
Idioma:
En
Revista:
J Infect Dis
Ano de publicação:
2014
Tipo de documento:
Article