The exocyclic olefin geometry control via Ireland-Claisen rearrangement: stereoselective total syntheses of Barmumycin and Limazepine E.
Org Lett
; 15(17): 4406-9, 2013 Sep 06.
Article
em En
| MEDLINE
| ID: mdl-23964608
ABSTRACT
Stereoselective total syntheses of Limazepine E and Barmumycin, potent, naturally occurring antitumor agents, are described. The total syntheses control the olefin geometry via a highly selective chelation-controlled Ireland-Claisen rearrangement of a seven-membered lactone-derived boron enolate for the synthesis of (E)-4-ethylidene proline, a crucial building block for a number of natural products.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pirrolidinas
/
Azepinas
/
Alcenos
/
Antineoplásicos
Idioma:
En
Revista:
Org Lett
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Letônia