Superoxide-mediated protection of Escherichia coli from antimicrobials.
Antimicrob Agents Chemother
; 57(11): 5755-9, 2013 Nov.
Article
em En
| MEDLINE
| ID: mdl-23979754
ABSTRACT
Antimicrobial lethality is promoted by reactive oxygen species (ROS), such as superoxide, peroxide, and hydroxyl radical. Pretreatment with subinhibitory concentrations of plumbagin or paraquat, metabolic generators of superoxide, paradoxically reduced killing for oxolinic acid, kanamycin, and ampicillin. These pretreatments also reduced an oxolinic acid-mediated ROS surge. Defects in SoxS MarA or AcrB eliminated plumbagin- and paraquat-mediated MIC increases but maintained protection from killing. Thus, superoxide has both protective and detrimental roles in response to antimicrobial stress.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Canamicina
/
Ácido Oxolínico
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Regulação Bacteriana da Expressão Gênica
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Superóxidos
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Escherichia coli K12
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Ampicilina
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Antibacterianos
Idioma:
En
Revista:
Antimicrob Agents Chemother
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos