Focal amplification of HOXD-harboring chromosome region is implicated in multiple-walled carbon nanotubes-induced carcinogenicity.
Nano Lett
; 13(10): 4632-41, 2013 Oct 09.
Article
em En
| MEDLINE
| ID: mdl-23984819
ABSTRACT
Multiple-walled carbon nanotubes (MWCNTs) may cause carcinogenesis. We found that long-term exposure to MWCNTs can induce irreversible oncogenic transformation of human bronchial epithelial cells and tumorigenicity in vivo. A genome-wide array-comparative genomic hybridization (aCGH) analysis revealed global chromosomal aberration in MWCNTs-treated clones, predominantly at chromosome 2q31-32, where the potential oncogenes HOXD9 and HOXD13 are located. Functional assays confirmed that this variation can modulate oncogenic signaling and plays a part in MWCNTs-induced tumorigenesis, suggesting that MWCNTs are carcinogens that act by altering genomic stability and oncogenic copy numbers.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
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Cromossomos
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Proteínas de Homeodomínio
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Nanotubos de Carbono
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Carcinogênese
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Proteínas de Neoplasias
Limite:
Humans
Idioma:
En
Revista:
Nano Lett
Ano de publicação:
2013
Tipo de documento:
Article