Structure homology and interaction redundancy for discovering virus-host protein interactions.
EMBO Rep
; 14(10): 938-44, 2013 Oct.
Article
em En
| MEDLINE
| ID: mdl-24008843
ABSTRACT
Virus-host interactomes are instrumental to understand global perturbations of cellular functions induced by infection and discover new therapies. The construction of such interactomes is, however, technically challenging and time consuming. Here we describe an original method for the prediction of high-confidence interactions between viral and human proteins through a combination of structure and high-quality interactome data. Validation was performed for the NS1 protein of the influenza virus, which led to the identification of new host factors that control viral replication.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas não Estruturais Virais
/
Interações Hospedeiro-Patógeno
/
Modelos Biológicos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
EMBO Rep
Assunto da revista:
BIOLOGIA MOLECULAR
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
França