BTNL8, a butyrophilin-like molecule that costimulates the primary immune response.
Mol Immunol
; 56(4): 819-28, 2013 Dec.
Article
em En
| MEDLINE
| ID: mdl-24036152
ABSTRACT
The role of the B7 family molecules in the regulation of the immune response is well documented. A large body of experimental evidence indicates that costimulatory molecules such as B7-1, B7-2, B7-DC, B7-H1, B7-H2, B7-H3 and B7-H4 are critical for initiation, maintenance and down-regulation of the immune response. However the immunological function of butyrophilin (BTN)-like molecules, which are a part of the expanded B7 family, is not known. Here, we demonstrate that the extracellular portion of human BTNL8 can augment Ag-induced activation of T lymphocytes. BTNL8 has two alternatively spliced forms B7-like and BTN-like. Both isoforms of BTNL8 were expressed concurrently in various human tissues. A putative BTNL8 receptor was detected only on resting T lymphocytes. Administration of BTNL8Ig fusion protein into mice promoted production of Ag-specific IgG during the primary, but not the secondary immune responses. BTNL8 may therefore play an essential role in priming of naïve T lymphocytes.
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MEDLINE
Assunto principal:
Ativação Linfocitária
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Linfócitos T
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Proteínas de Membrana
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Antígenos
Idioma:
En
Revista:
Mol Immunol
Ano de publicação:
2013
Tipo de documento:
Article