Curbing false discovery rates in interpretation of genome-wide expression profiles.
J Biomed Inform
; 47: 58-61, 2014 Feb.
Article
em En
| MEDLINE
| ID: mdl-24060601
ABSTRACT
Fisher's exact test is widely used in biomedical research, particularly in genomic profile analysis. Since in most databases, the frequency distribution of genes is right skewed, we show here that its use can lead to excessive false-positive discoveries. We propose to apply Zelen's exact test on a stratification of the gene set; this solves the false discovery problem, and should avoid misleading interpretations of lists of genes produced by various genome-wide analysis technologies.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Perfilação da Expressão Gênica
/
Estudo de Associação Genômica Ampla
Limite:
Humans
Idioma:
En
Revista:
J Biomed Inform
Assunto da revista:
INFORMATICA MEDICA
Ano de publicação:
2014
Tipo de documento:
Article