Transcriptome network-based method to identify genes associated with unruptured intracranial aneurysms.
Genet Mol Res
; 12(3): 3263-73, 2013 Sep 03.
Article
em En
| MEDLINE
| ID: mdl-24065667
ABSTRACT
Intracranial aneurysm is a balloon or sac-like dilatation of blood vessels inside the brain. Despite their importance, the biological mechanisms of intracranial aneurysms are not totally understood. We used public genome-wide gene expression profile data to identify potential genes that are involved in intracranial aneurysm in order to construct a regulation network. Some of the transcription factors and target genes that we identified in this network had been identified as related to intracranial aneurysm in previous studies. We found additional transcription factors and target genes that are apparently related to intracranial aneurysm with this method. The confirmation of previously identified genes and transcription factors supports the usefulness of this transcriptome network analysis for the identification of candidate genes involved in intracranial aneurysm.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Aneurisma Intracraniano
/
Perfilação da Expressão Gênica
/
Redes Reguladoras de Genes
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Genet Mol Res
Assunto da revista:
BIOLOGIA MOLECULAR
/
GENETICA
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
China