Discovery of (S,E)-3-(2-fluorophenyl)-N-(1-(3-(pyridin-3-yloxy)phenyl)ethyl)-acrylamide as a potent and efficacious KCNQ2 (Kv7.2) opener for the treatment of neuropathic pain.
Bioorg Med Chem Lett
; 23(22): 6188-91, 2013 Nov 15.
Article
em En
| MEDLINE
| ID: mdl-24070783
ABSTRACT
Acrylamide (S)-6, a potent and efficacious KCNQ2 (Kv7.2) opener, demonstrated significant activity in two models of neuropathic pain and in the formalin test, suggesting that KCNQ2 openers may be useful in the treatment of neuropathic pain including diabetic neuropathy.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Acrilamidas
/
Canal de Potássio KCNQ2
/
Neuralgia
Limite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2013
Tipo de documento:
Article