Diffusion-weighted imaging with acquisition of three b-values for response evaluation of neuroendocrine liver metastases undergoing selective internal radiotherapy.
Eur Radiol
; 24(2): 267-76, 2014 Feb.
Article
em En
| MEDLINE
| ID: mdl-24081644
ABSTRACT
OBJECTIVES:
To evaluate diffusion-weighted MRI with acquisition of three b-values and calculation of fractioned ADCs for response evaluation of neuroendocrine liver metastases undergoing selective internal radiotherapy (SIRT).METHODS:
Ten consecutive patients with neuroendocrine liver metastases underwent MRI before and following SIRT. Diffusion-weighted imaging included acquisition of the b-values 0, 50 and 800 s/mm(2) and calculation of ADC(50,800), ADC(0,50) and ADC(0,800) maps. According to therapy response, lesions were categorised into group A [≥20% reduction of the longest diameter (LD) in comparison to baseline MRI] and group B (<20% reduction of the LD).RESULTS:
Twelve out of 31 metastases were categorised as group A and 19 out of 31 metastases were categorised as group B. Pretherapeutic values of ADC(0,800) and ADC(50,800) did not differ significantly between the two groups; however, ADC(0,50) was 32% lower in group A (P = 0.049). ADC(0,800) and ADC(50,800) increased significantly after therapy in both groups, however, group differences were not statistically significant. Conversely, the increase in ADC(0,50) was about a factor of 7 larger in group A than in group B (P = 0.023).CONCLUSIONS:
Our study showed that the ADC(0,50) is a promising biomarker for response assessment of neuroendocrine liver metastases following SIRT. KEY POINTS ⢠Diffusion-weighted MRI offers new information about neuroendocrine hepatic metastases. ⢠Evaluation of perfusion and diffusion components requires fractioned apparent diffusion coefficients (ADCs). ⢠Perfusion effects represented by ADC (0.50) can be observed in neuroendocrine metastases. ⢠Pretherapeutic ADC (0.50) was significantly lower in metastases with a response ≥20%. ⢠Such biomarkers may help evaluate liver metastases in patients undergoing therapy.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Braquiterapia
/
Tumores Neuroendócrinos
/
Imagem de Difusão por Ressonância Magnética
/
Neoplasias Gastrointestinais
/
Neoplasias Hepáticas
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Eur Radiol
Assunto da revista:
RADIOLOGIA
Ano de publicação:
2014
Tipo de documento:
Article