Grid polymeric scaffolds with polypeptide gel filling as patches for infarcted tissue regeneration.
Annu Int Conf IEEE Eng Med Biol Soc
; 2013: 6961-4, 2013.
Article
em En
| MEDLINE
| ID: mdl-24111346
ABSTRACT
Scaffolds of poly(ethyl acrylate) (PEA) with interconnected cylindrical orthogonal pores filled with a self-assembling peptide (SAP) gel are here proposed as patches for infarcted tissue regeneration. These combined systems aim to support cell therapy and meet further requirements posed by the application the three-dimensional architecture of the elastomeric scaffold is expected to lodge the cells of interest in the damaged zone avoiding their death or migration, and at the same time conduct cell behavior and give mechanical support if necessary; the ECM-like polypeptide gel provides a cell-friendly aqueous microenvironment, facilitates diffusion of nutrients and cell wastes and is expected to improve the distribution and viability of the seeded cells within the pores and stimulate angiogenesis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Polímeros
/
Regeneração
/
Alicerces Teciduais
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Géis
Limite:
Animals
Idioma:
En
Revista:
Annu Int Conf IEEE Eng Med Biol Soc
Ano de publicação:
2013
Tipo de documento:
Article