Val158Met COMT polymorphism and risk of aggression in alcohol dependence.
Addict Biol
; 20(1): 197-204, 2015 Jan.
Article
em En
| MEDLINE
| ID: mdl-24118473
ABSTRACT
Aggression, violence and antisocial behavior are common in alcoholism, but their biological basis is poorly understood. Several studies and recent meta-analyses indicate that in schizophrenia the catecholamine-O-methyltransferase (COMT) Val158Met genotype may be associated with aggression, most often in methionine allele carriers. We tested this hypothesis in a sample of treatment-seeking alcohol-dependent in-patients (293 German patients and 499 controls, and additional 190 Polish patients as replication sample). As expected, patients with a history of violent or non-violent crime were more often male, had an earlier onset of alcoholism and more withdrawal seizures and delirium tremens, and were more likely to have a history of suicide attempts. COMT genotype was not associated with a history of violent or non-violent crime. More studies are needed on the neurobiological basis of aggression and violence in alcoholism.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Violência
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Catecol O-Metiltransferase
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Agressão
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Alcoolismo
Tipo de estudo:
Etiology_studies
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Observational_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Addict Biol
Assunto da revista:
TRANSTORNOS RELACIONADOS COM SUBSTANCIAS
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Suíça