The pore-forming bacterial effector, VopQ, halts autophagic turnover.
Autophagy
; 9(12): 2169-70, 2013 Dec.
Article
em En
| MEDLINE
| ID: mdl-24145145
ABSTRACT
Vibrio parahemolyticus Type III effector VopQ is both necessary and sufficient to induce autophagy within one hour of infection. We demonstrated that VopQ interacts with the Vo domain of the conserved vacuolar H(+)-ATPase. Membrane-associated VopQ subsequently forms pores in the membranes of acidic compartments, resulting in immediate release of protons without concomitant release of lumenal protein contents. These studies show how a bacterial pathogen can compromise host ion potentials using a gated pore-forming effector to equilibrate levels of small molecules found in endolysosomal compartments and disrupt cellular processes such as autophagy.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Autofagia
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Proteínas de Bactérias
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Vibrio parahaemolyticus
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Fatores de Virulência
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Proteínas Citotóxicas Formadoras de Poros
Limite:
Humans
Idioma:
En
Revista:
Autophagy
Ano de publicação:
2013
Tipo de documento:
Article