Effect of helminth-induced immunity on infections with microbial pathogens.
Nat Immunol
; 14(11): 1118-1126, 2013 Nov.
Article
em En
| MEDLINE
| ID: mdl-24145791
ABSTRACT
Helminth infections are ubiquitous worldwide and can trigger potent immune responses that differ from and potentially antagonize host protective responses to microbial pathogens. In this Review we focus on the three main killers in infectious disease-AIDS, tuberculosis and malaria-and critically assesses whether helminths adversely influence host control of these diseases. We also discuss emerging concepts for how M2 macrophages and helminth-modulated dendritic cells can potentially influence the protective immune response to concurrent infections. Finally, we present evidence advocating for more efforts to determine how and to what extent helminths interfere with the successful control of specific concurrent coinfections.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tuberculose
/
Células Dendríticas
/
Síndrome da Imunodeficiência Adquirida
/
Helmintíase
/
Macrófagos
/
Malária
Limite:
Animals
/
Humans
País/Região como assunto:
Africa
/
Asia
Idioma:
En
Revista:
Nat Immunol
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos