Conjugation of peptide nucleic acid with a pyrrole/imidazole polyamide to specifically recognize and cleave DNA.
Angew Chem Int Ed Engl
; 52(51): 13681-4, 2013 Dec 16.
Article
em En
| MEDLINE
| ID: mdl-24155125
ABSTRACT
Cut loose A pseudocomplementary peptide nucleic acid was tethered to a pyrrole/imidazole hairpin polyamide, and was used to selectively target a specific DNA sequence. Binding even occurs under high salt conditions. Furthermore, the conjugate facilitated sequence-specific scission of long dsDNA. This simple approach promises to resolve the technical difficulties in targeting DNA sequences with PNA.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pirróis
/
DNA
/
Ácidos Nucleicos Peptídicos
/
Amidas
/
Imidazóis
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Ano de publicação:
2013
Tipo de documento:
Article