Human plasmacytoid dendritic cells sense lymphocytic choriomeningitis virus-infected cells in vitro.
J Virol
; 88(1): 752-7, 2014 Jan.
Article
em En
| MEDLINE
| ID: mdl-24155390
ABSTRACT
We previously reported that exosomal transfer of hepatitis C virus (HCV) positive-strand RNA from human Huh-7 hepatoma cells to human plasmacytoid dendritic cells (pDCs) triggers pDC alpha/beta interferon (IFN-α/ß) production in a Toll-like receptor 7 (TLR7)-dependent, virus-independent manner. Here we show that human pDCs are also activated by a TLR7-dependent, virus-independent, exosomal RNA transfer mechanism by human and mouse hepatoma and nonhepatoma cells that replicate the negative-strand lymphocytic choriomeningitis virus (LCMV).
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Células Dendríticas
/
Vírus da Coriomeningite Linfocítica
Limite:
Humans
Idioma:
En
Revista:
J Virol
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Estados Unidos