Theophylline reduces the response to nasal challenge with antigen.
Am J Med
; 79(6A): 43-7, 1985 Dec 20.
Article
em En
| MEDLINE
| ID: mdl-2417477
ABSTRACT
A nasal challenge model of allergic rhinitis was used to determine if pretreatment with oral theophylline reduces histamine release in vivo. Ten subjects were entered into a double-blind, cross-over trial. The results showed that both the physiologic response (sneezing) (p = 0.02) and the amount of mediators (histamine, kinins, toluene sulfonyl arginine methyl ester esterase activity) (p less than 0.01 for all) released into nasal secretions were significantly reduced after one week of pretreatment with theophylline. At the time of challenge, the serum concentrations of theophylline were between 8 and 22 micrograms/ml. It is speculated that the ability of theophylline to block the clinical response to antigen challenge and to decrease the release of mast cell mediators contributes to its clinical efficacy in the treatment of asthma.
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Base de dados:
MEDLINE
Assunto principal:
Teofilina
/
Testes de Provocação Brônquica
Tipo de estudo:
Clinical_trials
Limite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Am J Med
Ano de publicação:
1985
Tipo de documento:
Article