The assessment of pulsed dye laser treatment of port-wine stains with reflectance confocal microscopy.
J Cosmet Laser Ther
; 16(1): 21-5, 2014 Jan.
Article
em En
| MEDLINE
| ID: mdl-24215420
ABSTRACT
BACKGROUND:
Reflectance confocal microscopy (RCM) is a noninvasive technique for evaluating cutaneous lesions with cellular level resolution close to conventional histopathology. The aim of this study is to observe the vascular changes in Port-wine (PWS) lesions and assess the clinical efficacy of Pulsed Dye Laser (PDL) treatment by examining vessel diameter and density with RCM. MATERIALS ANDMETHODS:
Eleven adult patients with PWS, each had four test patches carried out with different pulse durations (1.5, 3, 6, and 10 ms), respectively; fluences of 9-12 J/cm²; and a spot size of 7 mm. The PDL treatment was repeated 3-5 times at a 2-month interval. Photographs and measurements with RCM were taken before each treatment and 2 months after the last treatment.RESULTS:
The PDL treatment exhibited increasing clearance with reducing pulse durations. Vessel diameters and densities were significantly decreased in the same pulse-duration groups after treatment. There was significant difference between 1.5 ms pulse-duration group and other pulse-duration groups in reducing blood vessel diameter at the depth of 150 µm.CONCLUSIONS:
RCM can be used to assess the clinical efficacy of PDL treatment.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Microscopia Confocal
/
Mancha Vinho do Porto
/
Lasers de Corante
/
Microvasos
Limite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Cosmet Laser Ther
Assunto da revista:
DERMATOLOGIA
Ano de publicação:
2014
Tipo de documento:
Article