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A SCARECROW-RETINOBLASTOMA protein network controls protective quiescence in the Arabidopsis root stem cell organizer.
Cruz-Ramírez, Alfredo; Díaz-Triviño, Sara; Wachsman, Guy; Du, Yujuan; Arteága-Vázquez, Mario; Zhang, Hongtao; Benjamins, Rene; Blilou, Ikram; Neef, Anne B; Chandler, Vicki; Scheres, Ben.
Afiliação
  • Cruz-Ramírez A; Department of Molecular Genetics, Utrecht University, Utrecht, The Netherlands ; Laboratorio Nacional de Genmica para la Biodiversidad, Cinvestav Sede Irapuato, Irapuato, Mexico.
PLoS Biol ; 11(11): e1001724, 2013 Nov.
Article em En | MEDLINE | ID: mdl-24302889
Quiescent long-term somatic stem cells reside in plant and animal stem cell niches. Within the Arabidopsis root stem cell population, the Quiescent Centre (QC), which contains slowly dividing cells, maintains surrounding short-term stem cells and may act as a long-term reservoir for stem cells. The RETINOBLASTOMA-RELATED (RBR) protein cell-autonomously reinforces mitotic quiescence in the QC. RBR interacts with the stem cell transcription factor SCARECROW (SCR) through an LxCxE motif. Disruption of this interaction by point mutation in SCR or RBR promotes asymmetric divisions in the QC that renew short-term stem cells. Analysis of the in vivo role of quiescence in the root stem cell niche reveals that slow cycling within the QC is not needed for structural integrity of the niche but allows the growing root to cope with DNA damage.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Arabidopsis / Meristema / Proteínas de Arabidopsis Idioma: En Revista: PLoS Biol Assunto da revista: BIOLOGIA Ano de publicação: 2013 Tipo de documento: Article País de afiliação: México

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Arabidopsis / Meristema / Proteínas de Arabidopsis Idioma: En Revista: PLoS Biol Assunto da revista: BIOLOGIA Ano de publicação: 2013 Tipo de documento: Article País de afiliação: México