[Surgical treatment of renal-cell carcinoma in von Hippel-Lindau disease]. / Tratamiento quirurgico del carcinoma de celulas renales en la enfermedad de von Hippel-Lindau.
Rev Invest Clin
; 65(4): 318-22, 2013.
Article
em Es
| MEDLINE
| ID: mdl-24304732
ABSTRACT
OBJECTIVE:
To describe the clinical outcome of surgical treatment of renal-cell carcinoma in patients with von Hippel-Lindau disease. To analyze the clinical, demographic and histopathological characteristics. MATERIAL ANDMETHODS:
From a total of 468 patients with renal-cell carcinoma treated surgically at our institution from 1982 to 2010, a series of 8 with von Hippel-Lindau disease were identified. Relevant variables included tumor recurrence, surgical approach, recurrence rate and mid-term preserved renal function.RESULTS:
Eight patients with von Hippel-Lindau disease and renal cell carcinoma were identified; 7 were treated with nephron-sparing surgery and 1 with radical nephrectomy. During the follow-up of 89.3 ± 67.5 months, we found ipsilateral tumor recurrence in two patients and contralateral in another one. Mean survival time was 72 months in seven out of eight patients who also preserved normal renal function; one patient with uncontrolled diabetes died from complications of chronic kidney disease five years after surgery.CONCLUSIONS:
Nephron-sparing surgery offers acceptable oncologic and functional results for patients with renal cell carcinoma and Von Hippel-Lindau disease.
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Base de dados:
MEDLINE
Assunto principal:
Carcinoma de Células Renais
/
Doença de von Hippel-Lindau
/
Neoplasias Renais
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Es
Revista:
Rev Invest Clin
Assunto da revista:
MEDICINA
Ano de publicação:
2013
Tipo de documento:
Article