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Association of the estrogen receptor-ß gene RsaI and AluI polymorphisms with human idiopathic thin endometrium.
Le, A W; Wang, Z H; Yuan, R; Shan, L L; Xiao, T H; Zhuo, R; Shen, Y.
Afiliação
  • Le AW; Department of Obstetrics and Gynecology, Nanshan Affiliated Hospital of Guangdong Medical College, Shenzhen, China.
Genet Mol Res ; 12(4): 5978-85, 2013 Nov 26.
Article em En | MEDLINE | ID: mdl-24338391
ABSTRACT
The aim of this study was to investigate the potential correlation between polymorphisms of the estrogen receptor (ER)-ß gene (RsaI and AluI) and ethnic Han Chinese human idiopathic thin endometrium. A total of 120 patients with idiopathic thin endometrium and 120 sterility patients with normal endometrium thickness (controls) were included in the study. RsaI and AluI polymorphisms of the ER-ß gene were analyzed with polymerase chain reaction-restriction fragment length polymorphism. The distribution of polymorphisms, genotype, allele, and haplotype was compared between the 2 groups. A significant difference in the RsaI genotype was observed between idiopathic thin endometrium patients and controls. The distribution of the R allele of the RsaI polymorphism in idiopathic thin endometrium patients was 37.1% compared with 48.3% in controls. The odds ratio was 0.630 (95% confidence interval = 0.438 to 0.907, P = 0.013). No significant difference in the genotype of the AluI polymorphism was found between the two groups. The linkage disequilibrium between RsaI and AluI haploids was not significant in either group, with D' values of 0.2036 and 0.0685 in the idiopathic thin endometrium patients and controls, respectively. The results of this study suggest a potential role of the ER-ß gene polymorphisms in the etiology of idiopathic atrophic endometrium and the R allele as a potential protective factor in ethnic Han Chinese.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polimorfismo de Fragmento de Restrição / Receptor beta de Estrogênio / Endométrio / Infertilidade Feminina Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans Idioma: En Revista: Genet Mol Res Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2013 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polimorfismo de Fragmento de Restrição / Receptor beta de Estrogênio / Endométrio / Infertilidade Feminina Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans Idioma: En Revista: Genet Mol Res Assunto da revista: BIOLOGIA MOLECULAR / GENETICA Ano de publicação: 2013 Tipo de documento: Article País de afiliação: China