Juvenile play experience does not affect nicotine sensitization and voluntary consumption of nicotine in adult rats.
Dev Psychobiol
; 56(5): 1052-60, 2014 Jul.
Article
em En
| MEDLINE
| ID: mdl-24347393
ABSTRACT
Juvenile play experiences promote behavioral flexibility in rats. If other early positive experiences, such as tactile stimulation, are given prior to exposure to psychostimulants, the behavioral response to the drug is attenuated. The objective of the present study was to determine if the experience of juvenile play behavior would attenuate the response to nicotine. Two experiments were conducted (1) behavioral sensitization to nicotine exposure, and (2) voluntary consumption of nicotine. For both experiments, rats were reared either with three same-sex peers (play group) or one adult (no play group) during their juvenile period. Then, as adults, half of each group was exposed to repeated injections of nicotine and the other half to saline. Prior play experience had no effect on behavioral sensitization or on voluntary consumption of nicotine. It remains to be determined whether juvenile experience with play influences the rewarding properties of nicotine in social contexts as adults.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Jogos e Brinquedos
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Comportamento Animal
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Estimulantes do Sistema Nervoso Central
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Atividade Motora
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Nicotina
Limite:
Animals
Idioma:
En
Revista:
Dev Psychobiol
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Canadá