Association study of angiotensin converting enzyme gene polymorphism with elderly diabetic hypertension and lipids levels.
Lipids Health Dis
; 12: 187, 2013 Dec 19.
Article
em En
| MEDLINE
| ID: mdl-24354906
ABSTRACT
OBJECTIVE:
To investigate the relationship between angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and diabetic essential hypertension in elderly population.METHODS:
Polymerase chain reaction (PCR) technique was used in 260 elderly normal control patients, 205 elderly hypertensive patients and 138 elderly diabetic hypertensive patients to detect the I/D polymorphism in ACE gene.RESULTS:
DD genotype frequency (0.352) and D allele frequency (0.543) in elderly hypertensive patients were higher than those in the normal control patients. DD genotype (0.421) and D allele frequency (0.579) in elderly diabetic hypertensive patients were significantly higher than those in the control patients (0.133 and 0.250). The differences of DD genotype and D allele frequency between the elderly hypertensive patients and the elderly diabetic hypertensive patients were not significant (P > 0.05).CONCLUSION:
ACE gene deletion is a risk factor for hypertension but is not a risk factor for diabetes in elderly population.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Sequência de Bases
/
Deleção de Sequência
/
Peptidil Dipeptidase A
/
Diabetes Mellitus Tipo 2
/
Hipertensão
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Lipids Health Dis
Assunto da revista:
BIOQUIMICA
/
METABOLISMO
Ano de publicação:
2013
Tipo de documento:
Article