Synthesis of novel indenoquinoxaline derivatives as potent &#945;-glucosidase inhibitors.

Khan, Madiha Sahar; Munawar, Munawar Ali; Ashraf, Mohammad; Alam, Umber; Ata, Athar; Asiri, Abdullah Mohamed; Kousar, Samina; Khan, Misbahul Ain

Synthesis of novel indenoquinoxaline derivatives as potent α-glucosidase inhibitors.

Khan, Madiha Sahar; Munawar, Munawar Ali; Ashraf, Mohammad; Alam, Umber; Ata, Athar; Asiri, Abdullah Mohamed; Kousar, Samina; Khan, Misbahul Ain.

Afiliação

Khan MS; Institute of Chemistry, University of the Punjab, Lahore 54590, Pakistan.
Munawar MA; Institute of Chemistry, University of the Punjab, Lahore 54590, Pakistan. Electronic address: mamunawar.chem@pu.edu.pk.
Ashraf M; Department of Biochemistry and Biotechnology, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.
Alam U; Department of Biochemistry and Biotechnology, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.
Ata A; Department of Chemistry, University of Winnipeg, 515 Portage Avenue, Winnipeg MB R3B 2E9, Canada.
Asiri AM; Centre of Excellence for Advanced Materials Research (CEAMR), King Abdulaziz University, PO Box 80203, Jeddah 21589, Saudi Arabia.
Kousar S; Institute of Chemistry, University of the Punjab, Lahore 54590, Pakistan.
Khan MA; Institute of Chemistry, University of the Punjab, Lahore 54590, Pakistan; Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.

Bioorg Med Chem ; 22(3): 1195-200, 2014 Feb 01.

Article em En | MEDLINE | ID: mdl-24398385

ABSTRACT

ABSTRACT

A series of new N-(11H-Indeno[1,2-b]quinoxalin-11-ylidene)benzohydrazide derivatives (3a-3p) were synthesized and evaluated for their α-glucosidase inhibitory activity. The synthesized compounds 3d, 3f, 3g, 3k, 3n, 3p and 4 showed significant α-glucosidase inhibitory activity as compared to acrabose, a standard drug used to treat type II diabetes. Structures of the synthesized compounds were determined by using FT-IR, (1)H NMR, (13)C NMR, mass spectrometry and elemental analysis techniques.

Assuntos

Inibidores Enzimáticos/química; Inibidores Enzimáticos/farmacologia; Inibidores de Glicosídeo Hidrolases; Acarbose/farmacologia; Técnicas de Química Sintética; Inibidores Enzimáticos/síntese química; Hipoglicemiantes/farmacologia; Imidazóis/química; Espectroscopia de Ressonância Magnética; Estrutura Molecular; Espectroscopia de Infravermelho com Transformada de Fourier; Relação Estrutura-Atividade

Palavras-chave

1,2-Di(11H-indeno[2,1-b]quioxalin-11-ylidene)hydrazine; 11H-Indeno[1,2-b]quinoxalin-11-one; N-(11H-Indeno[1,2-b]quinoxalin-11-ylidene)benzohydrazides; α-Glucosidase inhibitors

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores Enzimáticos / Inibidores de Glicosídeo Hidrolases Idioma: En Revista: Bioorg Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Paquistão

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